Wednesday 28 April 2010

it's not a problem if you forget your phone number,

but never forget: 0157:H7.

because an infection by that strain of E.coli is often followed by a H.U.S (hemolytic uremic syndrome), which presents with:

microangiopathic hemolytic anemia, decreased heptaglobin, petechia.
renal failure (increased B.U.N and creatinine).
THROMBOCYTOPENIA.

now if you add the symptoms of altered mental status and fever to the above triad, you get T.T.P, something quite different all together. you can remember its symptoms using the mnemonics FATRN:
Fever
Anemia
Thrombocytopenia
Renal abnormalities
Neuro abnormalities (seizure, confusion, aphasia, headache, coma)

remember: both H.U.S and T.T.P have normal coagulation (normal PT/PTT) and have an increase in LDH.

Here we go~

Hereditary spherocytosis is the only hemolytic anemia with an enlarged spleen.

There are two hemolytic conditions that cause biliary stones to form:

-sickle cell disease AND
-hereditary spherocytosis

You can have B12 deficiency without accompanying anemia, but not without a neuro deficit.